Search results for "Tourette's syndrome"

showing 2 items of 2 documents

Behavioral fragmentation in the D1CT-7 mouse model of Tourette's syndrome.

2017

Aim The transgenic D1CT-7 mouse is one of the best-characterized animal models of Tourette's syndrome (TS), exhibiting spontaneous tic-like Head-Body Twitches (HBT) and deficits in sensorimotor gating. This study is aimed at evaluating the behavioral dynamics of these mutants and their potential relevance to TS. Methods The behavior of D1CT-7 and Wild Type littermates was firstly assessed by considering frequencies and durations. To detect recurrent real-time behavioral sequences, the multivariate T-pattern analysis was employed. Analyses of transition probabilities among behaviors further provided an overall picture of the behavioral dynamics. Results T-patterns and transition matrices rev…

0301 basic medicineGenetically modified mouseMaleCholera ToxinTransgeneTourette's syndromeMice Transgenictransition matriceBiologyMotor ActivityTourette syndromeOpen fieldStatistics Nonparametric03 medical and health sciencesMice0302 clinical medicineSniffingPhysiology (medical)medicineAnimalsPharmacology (medical)tic disorderGait Disorders NeurologicPharmacologyMice Inbred BALB CD1CT-7Behavior AnimalReceptors Dopamine D1Wild typeBehavioral patternT-pattern analysiOriginal Articlesmedicine.diseasePhenotypeDisease Models Animal030104 developmental biologyPsychiatry and Mental HealthMotor SkillsExploratory BehaviorNeuroscience030217 neurology & neurosurgeryTourette SyndromeCNS neurosciencetherapeutics
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Time processing in children with Tourette's syndrome.

2010

Background: Tourette syndrome (TS) is characterized by dysfunctional connectivity between prefrontal cortex and sub-cortical structures, and altered meso-cortical and/or meso-striatal dopamine release. Since time processing is also regulated by fronto-striatal circuits and modulated by dopaminergic transmission, we hypothesized that time processing is abnormal in TS. Methods: We compared time processing abilities between nine children with TS-only (i.e. without major psychiatric comorbidities) and 10 age-matched healthy children, employing a time reproduction task in which subjects actively reproduce different temporal intervals, and a time comparison task in which subjects judge whether a …

Malemedicine.medical_specialtyTic severityPhysiologicalCognitive NeuroscienceMatched-Pair AnalysisShort-term memoryPoison controlExperimental and Cognitive PsychologyTourette's syndrome temporal processing time comparison time reproduction tic severityTic severity; Time comparison; Time reproduction; Tourette's syndromel; Case-Control Studies; Child; Humans; Imitative Behavior; Male; Matched-Pair Analysis; Pattern Recognition Physiological; Psychomotor Performance; Reference Values; Time Perception; Tourette Syndrome; Cognitive Neuroscience; Experimental and Cognitive Psychology; Neuropsychology and Physiological PsychologyPattern RecognitionAudiologyTourette's syndromelTourette syndromeArts and Humanities (miscellaneous)Reference ValuesDevelopmental and Educational PsychologyMemory spanmedicineHumansPrefrontal cortexChildTic severity; Time comparison; Time reproduction; Tourette's syndromel; Case-Control Studies; Child; Humans; Imitative Behavior; Male; Matched-Pair Analysis; Pattern Recognition Physiological; Psychomotor Performance; Reference Values; Time Perception; Tourette Syndrome; Neuropsychology and Physiological Psychology; Experimental and Cognitive Psychology; Developmental and Educational Psychology; Arts and Humanities (miscellaneous); Cognitive NeuroscienceIntelligence quotientWorking memoryCognitionmedicine.diseaseImitative BehaviorNeuropsychology and Physiological PsychologyCase-Control StudiesPattern Recognition PhysiologicalTime reproductionTime PerceptionTime comparisonPsychologyPsychomotor PerformanceCognitive psychologyTourette SyndromeBrain and cognition
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